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Item Details
| Title:
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PROTEIN-PROTEIN COMPLEXES
ANALYSIS, MODELING AND DRUG DESIGN |
| By: |
Zacharias, Martin Zacharias (Editor) |
| Format: |
Electronic book text |
| List price:
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£115.00 |
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We currently do not stock this item, please contact the publisher directly for
further information.
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| ISBN 10: |
1848163401 |
| ISBN 13: |
9781848163409 |
| Publisher: |
IMPERIAL COLLEGE PRESS |
| Pub. date: |
29 August, 2010 |
| Pages: |
401 |
| Synopsis: |
Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge be used to predict and design protein-protein interactions (interaction regions and complex structures)? What methods are currently employed to design protein-protein interactions, and how can we influence protein-protein interactions by mutagenesis and small-molecule drugs or peptide mimetics?The book consists of about 15 review chapters, written by experts, on the characterization of protein-protein interfaces, structure determination of protein complexes (by NMR and X-ray), theory of protein-protein binding, dynamics of protein interfaces, bioinformatics methods to predict interaction regions, and prediction of protein-protein complex structures (docking and homology modeling of complexes, etcetera.) and design of protein-protein interactions. It serves as a bridge between studying/analyzing protein-protein complex structures (interfaces), predicting interactions, and influencing/designing interactions. |
| Publication: |
UK |
| Imprint: |
Imperial College Press |
| Returns: |
Non-returnable |
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