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Item Details
| Title:
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GENETIC EFFECTS ON ENVIRONMENTAL VULNERABILITY TO DISEASE
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| By: |
Sir Michael Rutter (Editor) |
| Format: |
Other digital |
| List price:
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£54.00 |
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We currently do not stock this item, please contact the publisher directly for
further information.
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| ISBN 10: |
0470696788 |
| ISBN 13: |
9780470696781 |
| Publisher: |
JOHN WILEY AND SONS LTD |
| Pub. date: |
13 August, 2008 |
| Series: |
Novartis Foundation Symposia 293 |
| Pages: |
232 |
| Description: |
Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. |
| Synopsis: |
Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens. This book brings together contributions from experts from multiple disciplines who discuss:* How epidemiological cohort studies can better integrate physiological (mechanistic) measures;* How best to characterise subjects' vulnerability versus resilience by moving beyond single genetic polymorphisms;* How gene hunters can benefit from recruiting samples selected for known exposures;* How environmental pathogens can be used as tools for gene hunting;* How to deal with potential spurious (statistical) interactions, and* How genes can help explain fundamental demographic properties of disorders (e.g. sex distribution, age effects). |
| Publication: |
US |
| Imprint: |
Wiley-Blackwell |
| Returns: |
Non-returnable |
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