 |
|
|
Item Details
| Title:
|
THE CELLULAR RESPONSE TO THE GENOTOXIC INSULT
THE QUESTION OF THRESHOLD FOR GENOTOXIC CARCINOGENS |
| By: |
Helmut Greim (Editor), Richard J. Albertini (Editor), Tim Marrs |
| Format: |
Hardback |
| List price:
|
£169.99 |
| Our price: |
£152.99 |
| Discount: |
|
| You save:
|
£17.00 |
|
|
|
|
|
| ISBN 10: |
1849731772 |
| ISBN 13: |
9781849731775 |
| Availability: |
Reprinting. This item may be subject to delays or cancellation.
 Delivery
rates
|
| Stock: |
Currently 0 available |
| Publisher: |
ROYAL SOCIETY OF CHEMISTRY |
| Pub. date: |
4 May, 2012 |
| Series: |
Issues in Toxicology 13 |
| Pages: |
334 |
| Description: |
This book considers the exposure levels at which genotoxins pose a risk and describes the cellular mechanisms used against them. |
| Synopsis: |
Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer. Typically, a series of mutation events are needed before malignancy occurs so a single, small exposure may not result in disease. Also, cells have an armoury of defence mechanisms which, to a degree, counter the effects of mutagens. Distinguishing the point at which exposure to a carcinogen increases mutation rates beyond the background level is challenging. In fact, there is now general agreement that, for genotoxic carcinogens, no specific threshold can be identified. However, NOAELs (No Observed Adverse Effect Levels) may be used in the process of establishing a dose-response relationship. These denote the level of exposure at which there is no significant increase in adverse effects in the exposed population when compared to an appropriate control. Such a scientifically defendable threshold allows us to propose health based exposure limits for genotoxic carcinogens. This book describes the various cellular defence mechanisms individually and explains how they are regulated.The processes covered include metabolic inactivation, epigenetic regulation, scavenging mechanisms, DNA-repair and apoptosis. It also considers dose-dependent threshold mechanisms of carcinogenesis and the rate limiting parameters. Aimed at graduate level and above, the book discusses the consequences of genotoxic evaluation and urges readers to question the idea that even low exposures present a cancer risk. |
| Illustrations: |
100 black & white halftones |
| Publication: |
UK |
| Imprint: |
Royal Society of Chemistry |
| Returns: |
Returnable |
|
|
|
 |
|
|
|
|
|
No Cheese, Please!
A fun picture book for children with food allergies - full of friendship and super-cute characters!Little Mo the mouse is having a birthday party.
|
My Brother Is a Superhero
Luke is massively annoyed about this, but when Zack is kidnapped by his arch-nemesis, Luke and his friends have only five days to find him and save the world...
|
|
|
|
|