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Item Details
| Title:
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KINETIC ANALYSIS OF MACROMOLECULES
A PRACTICAL APPROACH |
| By: |
Kenneth Johnson (Editor) |
| Format: |
Paperback |
| List price:
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£102.50 |
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We currently do not stock this item, please contact the publisher directly for
further information.
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| ISBN 10: |
0198524943 |
| ISBN 13: |
9780198524946 |
| Publisher: |
OXFORD UNIVERSITY PRESS |
| Pub. date: |
18 September, 2003 |
| Series: |
Practical Approach Series |
| Pages: |
276 |
| Description: |
This new book in the Practical Approach Series contains reviews of state-of-the art kinetic methods applied to the functions and dynamics of proteins and nucleic acids. The book has been written by a team of experts, many of whom developed the methods discussed. |
| Synopsis: |
Modern enzymology can no longer rely upon indirect inferences derived by steady state kinetic analysis because these are often misleading. Rather, in the era of "New Enzymology", reactions at the active sites of enzyme are monitored by direct measurement of individual steps in the sequence to establish the pathway of reactions occurring. These quantitative methods can be directly related to high resolution structural information and define the underlying kinetic and thermodynamic basis for catalysis. The goal of a comprehensive kinetic analysis is to identify each step in the reaction pathway, define the rate and equilibrium constants for each step, identify all conformational and chemical intermediates, identify the rate-limiting steps, and ultimately establish the basis for enzymatic specificity and efficiency. This volume contains chapters contributed by leading experts in the application of modern kinetic methods to complex problems in the study of catalysis by both proteins and RNA catalysts. |
| Illustrations: |
numerous line figures, 13 halftones |
| Publication: |
UK |
| Imprint: |
Oxford University Press |
| Returns: |
Returnable |
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