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Item Details
Title:
HUMAN GENETIC DIVERSITY
FUNCTIONAL CONSEQUENCES FOR HEALTH AND DISEASE
By:
Julian C. Knight
Format:
Hardback
List price:
£120.00
Our price:
£105.00
Discount:
12.5
% off
You save:
£15.00
ISBN 10:
0199227691
ISBN 13:
9780199227693
Availability:
Usually dispatched within 1-3 weeks.
Delivery rates
Stock:
Currently
0
available
Publisher:
OXFORD UNIVERSITY PRESS
Pub. date:
6 August, 2009
Pages:
504
Description:
This book describes the remarkable progress which has been made in defining the extent and nature of human genetic variation. It provides a framework for understanding how research in this area is revolutionising our knowledge of human origins and the genetic basis of disease, as well as common traits such as obesity.
Synopsis:
The secrets of our genetic heritage are finally being unlocked. The massive scientific effort to sequence the human genome is in fact just the beginning of a long journey as the extraordinary genetic diversity that exists between individuals becomes clear. Work in this field promises much: to understand our evolutionary origins, to define us as individuals, to predict our risk of disease and to more effectively understand, treat and prevent illness. Contemporary genetic research is allowing the basis of both rare inherited disorders and common multifactorial diseases like asthma and diabetes to be more clearly defined. Huge investments are being made and great advances have been achieved, but the challenges remain daunting. This book provides an authoritative overview of this topical and very rapidly advancing field of biomedical research. Human Genetic Diversity describes the major classes of genetic variation and their functional consequences. A combination of cutting-edge research and landmark historical studies illustrate developments in the field, the rationale for current studies and likely future directions.Major structural variants at a chromosomal level are described, as well as copy number variation and sequence level genetic diversity. Evidence of selective pressures in human populations and insights into human evolution are illustrated. The book describes the development of linkage analysis and more recently genome-wide association studies to define the genetic basis of disease, current approaches to defining functional causative variants and the emerging fields of pharmacogenomics and individualised medicine.
Illustrations:
190 illustrations
Publication:
UK
Imprint:
Oxford University Press
Prizes:
Winner of Highly Commended: BMA Medical Book Awards for Basic and Clinical
Returns:
Returnable
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