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Item Details
Title: APOPTOSIS
THE MOLECULAR BIOLOGY OF PROGRAMMED CELL DEATH
By: Michael Jacobson (Editor), Nicola McCarthy (Editor)
Format: Paperback

List price: £112.50


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ISBN 10: 0199638497
ISBN 13: 9780199638499
Publisher: OXFORD UNIVERSITY PRESS
Pub. date: 11 April, 2002
Series: Frontiers in Molecular Biology 40
Pages: 346
Description: The number of cells within the human body is very tightly regulated: too many and we can devlop cancer, too few and we may lose cells that we cannot replace. The number of cells is controlled by several different mechanisms in different tissues, but all are triggered to commit suicide should too many be in one place at one time, or become damaged. This book examines how this process of cell suicide (apoptosis) is regulated, and how our understanding of this processmay lead to novel treatments for a wide variety of human diseases.
Synopsis: Apoptosis is a regulated form of cell demise that can be induced or blocked by groups of specific stimuli. Occurring in all living tissues, it is thought critical to the maintenance of homeostasis and is implicated in lowering susceptibility to tumour growth. Conversely, over-sensitivity to apoptotic triggers can cause cells to be lost inappropriately from tissues, as appears to occur in neurodegenerative diseases. This book examines the molecular pathways regulating apoptosis, progressing from the nematode worm through Drosphila to the more complex pathways evident in mammalian cells. Differences in the cell death pathway within specific tissues are addressed, as are the different genes that may act to regulate progressive steps.
Illustrations: numerous linedrawings, 6 halftones, 4pp colour plates
Publication: UK
Imprint: Oxford University Press
Returns: Returnable
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