| Title:
|
STATISTICAL APPROACHES TO GENE X ENVIRONMENT INTERACTIONS FOR COMPLEX PHENOTYPES
|
| By: |
Michael Windle (Editor) |
| Format: |
Hardback |
| List price:
|
£7.99 |
|
We currently do not stock this item, please contact the publisher directly for
further information.
|
|
|
|
|
|
| ISBN 10: |
0262034689 |
| ISBN 13: |
9780262034685 |
| Publisher: |
MIT PRESS LTD |
| Pub. date: |
8 July, 2016 |
| Series: |
Statistical Approaches to Gene x Environment Interactions for Complex |
| Pages: |
304 |
| Description: |
"This edited volume stemmed from the 3rd Annual Symposium of the University of Georgia's Center for Contextual Genetics and Prevention Science (CGAPS)... was held on June 19-20, 2012 in Athens, GA"--Preface. |
| Synopsis: |
Findings from the Human Genome Project and from Genome-Wide Association (GWA) studies indicate that many diseases and traits manifest a more complex genomic pattern than previously assumed. These findings, and advances in high-throughput sequencing, suggest that there are many sources of influence -- genetic, epigenetic, and environmental. This volume investigates the role of the interactions of genes and environment (G x E) in diseases and traits (referred to by the contributors as complex phenotypes) including depression, diabetes, obesity, and substance use. The contributors first present different statistical approaches or strategies to address G x E and G x G interactions with high-throughput sequenced data, including two-stage procedures to identify G x E and G x G interactions, marker-set approaches to assessing interactions at the gene level, and the use of a partial-least square (PLS) approach. The contributors then turn to specific complex phenotypes, research designs, or combined methods that may advance the study of G x E interactions, considering such topics as randomized clinical trials in obesity research, longitudinal research designs and statistical models, and the development of polygenic scores to investigate G x E interactions.ContributorsFatima Umber Ahmed, Yin-Hsiu Chen, James Y. Dai, Caroline Y. Doyle, Zihuai He, Li Hsu, Shuo Jiao, Erin Loraine Kinnally, Yi-An Ko, Charles Kooperberg, Seunggeun Lee, Arnab Maity, Jeanne M. McCaffery, Bhramar Mukherjee, Sung Kyun Park, Duncan C. Thomas, Alexandre Todorov, Jung-Ying Tzeng, Tao Wang, Michael Windle, Min Zhang |
| Reader Age: |
From 18 years |
| Illustrations: |
43 b&w illus. |
| Publication: |
US |
| Imprint: |
MIT Press |
| Returns: |
Returnable |
|
|