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Item Details
| Title:
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PAIN CONTROL
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| By: |
Hans-Georg Schaible (Editor) |
| Format: |
Paperback |
| List price:
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£229.99 |
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We currently do not stock this item, please contact the publisher directly for
further information.
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| ISBN 10: |
3662513579 |
| ISBN 13: |
9783662513576 |
| Publisher: |
SPRINGER-VERLAG BERLIN AND HEIDELBERG GMBH & CO. KG |
| Pub. date: |
12 October, 2016 |
| Edition: |
Softcover reprint of the original 1st ed. 2015 |
| Series: |
Handbook of Experimental Pharmacology 227 |
| Pages: |
309 |
| Synopsis: |
This volume addresses neuronal pain mechanisms at the peripheral, spinal and supraspinal level which are thought to significantly contribute to pain and which may be the basis for the development of new treatment principles. Chapters on nociceptive mechanisms in the peripheral nociceptive system address the concept of hyperalgesic priming, the role of voltage-gated sodium channels in different inflammatory and neuropathic pain states, the hyperalgesic effects of NGF in different tissues and in inflammatory and neuropathic pain states, and the contribution of proteinase activated receptors (PAR) to the development of pain in several chronic pain conditions. Chapters on nociceptive mechanisms in the spinal cord address the particular role of NO and of glial cell activation in the generation and maintenance of inflammatory and neuropathic pain and it discusses the potential role of local inhibitory interneurons, of the endogenous endocannabinoid system and the importance of non-neuronal immune mechanisms in opioid signaling in the control of pain. Furthermore, it is presented how spinal mechanisms contribute to the expression of peripheral inflammation. |
| Illustrations: |
9 black & white illustrations, 22 colour illustrations, biography |
| Publication: |
Germany |
| Imprint: |
Springer-Verlag Berlin and Heidelberg GmbH & Co. K |
| Returns: |
Returnable |
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